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Oxidative stress induced osteocyte apoptosis in steroid-induced femoral head necrosis

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The enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CR), which catalyzes the rate-limiting step in cholesterol biosynthesisconversion of HMG-CoA to mevalonic acidis modulated by both thiol redox balance and hepatic reactive oxygen species (ROS) [114, 115]

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